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Fusionopolis is located at one-north, Singapore's icon of the knowledge economy. Marketed as an R&D hotspot where the best minds among the infocomm, media, science and engineering minds converge, it offers a comprehensive live-work-play-and-learn environment to optimise opportunities for exploration, discussion and collaboration.

one-north is located along North Buona Vista Road, next to Singapore's acclaimed Science Parks and close to the Ministry of Education, National University of Singapore, National University Hospital, Singapore Polytechnic and Holland Village. These communities mutually benefit from the core development of one-north with potential collaborations, and complement the research hub’s live, work, research, entertainment and recreation facilities.

The area is served by a network of buses and mass rapid transit train.